Your Guide To The Best Brain Supplements

While experts agree a healthy diet and lifestyle are the most important components of supporting brain health, research suggests the supplements below can help fill important nutrient gaps in a person’s diet—and potentially support cognitive health and mood.

Of all the supplements recommended by experts for brain health, omega-3 fatty acids top the list. “Omega-3 fatty acids, particularly the long-chain fatty acids DHA and EPA present in fatty fish, are essential for the development of the brain and the eyes and have a significant influence on mental health at all ages,“ notes Eva De Angelis, licensed dietitian nutritionist and chef based in Argentina.

These fatty acids help reduce inflammation in the body and the brain and are associated with a reduced risk of cognitive decline, Alzheimer’s disease and dementia, adds Delk.

Omega-3s play important roles in the membranes of nerve cells, and people with neurodegenerative disorders tend to have lower levels of EPA and DHA. Furthermore, research suggests omega-3s may help protect against neurodegeneration and reduce risk of cognitive decline.

The recommended daily intake of omega-3 fatty acids for all adults is between 1.1 and 1.6 grams. A typical fish oil supplement provides about 1,000 milligrams (or about 1 gram) of fish oil, with about 300 milligrams of omega-3s specifically. Dosage varies widely, so check product labels carefully before choosing a supplement.

Creatine supplementation is often used for building muscle and improving athletic performance, but recent research suggests creatine may help improve brain function as well.

According to a 2022 research review in the journal Nutrients, creatine may aid recovery from concussion and mild traumatic brain injury, ease symptoms of depression, improve cognition and help protect against neurodegenerative diseases. In one study referenced in the review, creatine supplementation helped improve memory in older adults .

Creatine is a naturally occurring amino acid found in muscle tissue and the brain. It’s important for energy production, especially during times of increased metabolic demand, such as sleep deprivation.

According to the Internal Society of Sports Nutrition (ISSN), consuming up to 30 grams of creatine monohydrate daily for five years is safe for healthy individuals. If you choose to supplement with creatine, the ISSN recommends starting with a daily dose of around 0.3 grams of creatine per kilogram of body weight (for example, 20 grams of creatine for a 150-pound person) for five to seven days, followed by 3 to 5 grams daily thereafter. It’s important to stick to the recommended dosages, as ingesting too much creatine at once can cause damage to the liver or kidneys.

Research confirms what coffee lovers around the world suspect—caffeine improves cognitive performance. A 2016 research review in the journal Practical Neurology suggests caffeine can increase alertness and feelings of well-being, improve concentration and mood and help alleviate depression symptoms. It’s even associated with a reduced risk of cognitive decline and Alzheimer’s disease .

“Caffeine is very popular for cognitive function, as it has demonstrated neuroprotective benefits,” notes Susan Hewlings Ph.D., vice president of research affairs at Radicle Science.

Just don’t overdo it. Experts recommend limiting caffeine intake to no more than 400 milligrams (about five cups of coffee, depending on the brew strength) a day and no more than 200 milligrams per sitting. Excessive caffeine consumption can be associated with restlessness, insomnia and heart palpitations.

L-theanine is an amino acid found naturally in some mushrooms, as well as green and black teas. “It’s linked to an improvement in mental performance and focus in numerous studies,” notes Chicago-based registered dietitian Leah Johnston.

In one small study in the journal Neuropharmacology, participants who took 100 milligrams of L-theanine before a monitored two-hour task period made fewer errors during that time than those who received a placebo .

While there isn’t an established dose recommendation or upper limit for L-theanine supplementation, studies examining its effects on cognitive function often use daily doses between 100 and 250 milligrams. A cup of green tea provides between 8 to 30 milligrams of L-theanine.

The Safe And Effective Way To Boost Your Brain Power

Alpha BRAIN is a nootropic supplement that has been clinically proven to improve cognitive function. It's made with all-natural ingredients that have been shown to boost brainpower.

Though called the sunshine vitamin, vitamin D is actually a hormone, notes U.K.-based specialist dietitian Sascha Landskron. “Vitamin D has hundreds of important functions [in the body] and is essential for good brain health,” she adds.

Research shows vitamin D is important for early brain development, and deficiency is linked to conditions including dementia, depression, autism and schizophrenia. One 2017 study in Current Gerontology and Geriatrics Research suggests vitamin D helps maintain cognitive function in older adults .

While the best source of vitamin D is sun exposure, you may need a supplement during the winter months or if you work indoors, wear sunscreen, cover your skin, have darker skin or have obesity, advises Landskron. Good food sources of vitamin D include cod liver oil, fatty fish like salmon and trout, mushrooms and fortified cereals and milk.

For most adults, the ideal daily dose for vitamin D is 600 to 800 IU. However, people supplementing with vitamin D over the long term can experience adverse health effects over time, such as high calcium levels in the blood, which can block blood vessels or cause kidney stones. Consider getting your vitamin D levels checked and consulting with your health care provider to determine the correct vitamin D supplementation dose for your body’s needs.

“Found naturally in eggs, choline is an essential nutrient that helps your brain make acetylcholine, which is a neurotransmitter needed for memory and general cognition,” explains Jacques Jospitre, Jr., M.D., board-certified psychiatrist and co-founder of SohoMD in New York.

In one study of over 2,000 older adults, those who consumed high amounts of choline tended to have lower risk of cognitive decline . While more human clinical trials are needed, animal-based research shows some promise in regards to choline’s role in reducing amyloid plaques and Alzheimer’s disease risk, adds Dr. Jospitre.

Resveratrol, an antioxidant polyphenol abundant in grapes and red wine, may help protect cells from damage, improve blood flow to the brain and slow cognitive decline. “Taking resveratrol supplements could prevent the deterioration of the hippocampus, an important part of the brain associated with memory,” notes Adash Bajaj, M.D., an anti-aging and longevity specialist in Los Angeles.

According to the National Institutes of Health (NIH), supplementing with up to 1,500 milligrams of resveratrol daily for up to three months is considered safe. Higher doses up to 3,000 milligrams are also safe but more likely to cause stomach upset. Resveratrol can also slow blood clotting, so it should be avoided in people preparing for surgery or who take blood thinner medications.

“Lion’s mane mushrooms (Hericium erinaceus) are tied to a host of health benefits, including reducing inflammation, treating anxiety or depression and enhancing cognitive function,” notes Johnston.

According to New York-based prebiotic and gut health expert Kara Landau, lion’s mane mushrooms support oxygen flow to the brain and can enhance memory, focus and concentration. “I find incorporating [lion’s mane mushrooms] on a daily basis helps one have a clearer mind and be able to take on the day without the negative side effects of increasing caffeine [intake],” she says.

Landau recommends starting with 250 to 500 milligrams of lion’s mane mushrooms daily to gauge your body’s tolerance, working up to around 1 gram daily. Note that, similar to resveratrol, lion’s mane mushrooms can interfere with the body’s blood clotting abilities. It can also cause a rash for some people.

The eight B vitamins play essential roles in brain health. “The vitamin B complex is crucial for supporting healthy brain function and may protect against memory loss, cognitive decline and neurodegenerative diseases,” says De Angelis.

Vitamins B6, B9 (folate) and B12 specifically are necessary for the metabolism of homocysteine, a molecule created in methionine metabolism, notes De Angelis. “Chances of neurodegeneration and cognitive decline increase with high blood homocysteine levels because it can cause oxidative stress and DNA damage,” she explains.

Most people can meet their B vitamin needs through a nutritious, well-balanced diet. However, older adults, people who follow plant-based diets and those with certain medical conditions may need a supplement to meet their needs. The recommended dietary allowance (RDA) for vitamin B6 for adults is between 1.2 and 2 milligrams daily, the RDA for folate for adults is between 400 and 600 micrograms daily, and the RDA for vitamin B12 for adults is between 2.4 and 2.8 micrograms daily. Most B vitamins are safe, but consuming excessive amounts of vitamin B6 can lead to nerve damage.

Theobromine is a natural stimulant found in chocolate that helps people feel more alert without the jittery feeling often associated with caffeine-containing foods and beverages, explains Landau. While animal and in vitro studies suggest theobromine may be effective at enhancing cognitive performance by improving blood flow to the brain, more studies in humans are needed.

Landau recommends a daily cup of brewed cacao as a delicious, rich source of theobromine.

Gut health is another important factor for optimal cognitive function, according to Hewlings. “Probiotics can benefit cognition via the gut-brain axis,” she says, which connects the gastrointestinal tract and the central nervous system through bidirectional neural, hormonal and immune signaling pathways.

In a 2021 study in the Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 12 weeks of supplementation with a probiotic combination of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI specifically appeared to improve brain function and decrease perceived stress in healthy older adults .

Prebiotics—non-digestible fibers in fruits, vegetables and grains—also support gut health by providing food for healthy gut bacteria. Landau recommends prebiotics called galacto-oligosaccharides (GOS) for both gut health and mood support. “GOS is a specific prebiotic that’s proven to support mental health,” she says. According to Landau, as little as 5.5 grams of GOS daily may help relieve anxiety.

In addition to probiotic and prebiotic supplements, you can support healthy gut flora by eating a wide range of fruits, vegetables and grains rich in prebiotic fiber, as well as fermented foods like kimchi, yogurt and sauerkraut that naturally contain probiotic bacteria.

While magnesium has many important physiological functions, its effect on brain health and cognition is only starting to come into focus. Magnesium supports normal neural function by protecting brain and nervous system cells from degeneration. Multiple studies suggest low magnesium consumption is associated with higher risk of cognitive impairment and dementia.

A 2022 study of over 2,500 people ages 60 and older found those who consumed the highest amounts of magnesium through food and supplements had higher scores on cognitive tests compared to those who consumed the least amounts of magnesium . Another long-term study found low magnesium levels during middle age to be associated with increased risk of dementia but not cognitive decline . However, in both studies, it’s unclear whether low levels of magnesium increase the risk of dementia or if people with dementia have low levels of magnesium for some other reason.

Magnesium is widely available in many plant- and animal-based foods, including leafy green vegetables like spinach, legumes, nuts, seeds and whole grains. The RDA for magnesium is between 310 and 420 milligrams for adult men and women.

Healthy people don’t need to worry about getting too much magnesium from food—the kidneys filter out magnesium the body doesn’t need. But high doses of magnesium supplements can lead to gastrointestinal issues like nausea and diarrhea or even toxicity when taken in excess.

Ashwagandha is a shrub used in the traditional Ayurvedic system of medicine to help enhance memory and reduce stress. Emerging research suggests ashwagandha may help improve cognitive function.

In one small but well-designed 2017 study in the Journal of Dietary Supplements, 50 adults with mild cognitive impairment received either 300 milligrams of ashwagandha root extract twice daily or a placebo for eight weeks. Those taking ashwagandha experienced significant improvements in memory, executive function, attention and information-processing speed compared to those who took a placebo .

In another 2021 study in Evidence-Based Complementary Alternative Medicine, healthy but stressed adults who took 300 milligrams of sustained-release ashwagandha extract daily for 90 days experienced significantly improved memory and focus, as well as psychological well-being, sleep quality and reduced stress compared to those who took a placebo .

Ashwagandha is commonly used in doses up to 1,000 milligrams daily for up to 12 weeks. While ashwagandha may be used safely in the short term, its long-term safety isn’t known, and large doses may lead to gastrointestinal upset or, rarely, liver problems.

According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative medications and thyroid hormones.

Consult your health care provider before taking ashwagandha to determine a proper dose for your needs and ensure it’s safe for you and medications you take. People who are pregnant or breastfeeding should avoid taking ashwagandha.

Formulas Built For Your Brain Chemistry

Thesis formulas are backed by the latest research to ensure they meet your body’s needs efficiently and are third party lab tested to help you feel more motivated, increase focus and raise your energy level.

Phosphatidylserine (PS) is a class of phospholipids naturally found in brain tissue membranes. PS plays a critical role in communication throughout the nervous system by activating important signaling pathways and affecting the release of chemical messengers known as neurotransmitters. Studies suggest supplementing with PS can help protect brain health, lower risk of central nervous system diseases like Alzheimer’s and Parkinson’s disease, and improve cognitive function by reducing inflammation in the brain.

Observing the effect of phosphatidylserine on cognitive function in older adults, a 2022 review and meta-analysis in the Korean Journal of Food Science and Technology found PS supplementation at a level of 300 milligrams daily may improve cognitive function and memory without side effects .

However, many of the available studies on PS are dated, small and of relatively short duration. While more studies are needed to know whether supplementing with PS can improve brain health and cognition, the existing research seems promising.

There’s currently no recommended dose of PS, but studies suggest doses between 300 and 500 milligrams per day are safe and free of side effects.

One of the simplest ways to support brain health is to stay hydrated. About 73% of the brain and central nervous system is composed of water.

“Hydration is key for allowing nutrients into the brain and for toxins to get out of the brain,” explains Dr. Jospitre. “It sounds simple, but ensuring adequate water intake is very important to ideal brain health, and most people typically don’t get enough.

The Institute of Medicine of the National Academies recommends adult women consume about 11 cups and men about 15 cups of water daily, including fluid from fruits, vegetables and other water-rich foods you eat.

However, even water can be toxic in very large quantities. If you drink excessive amounts of water faster than your kidneys can process it, it can deplete the sodium levels in your blood to dangerously low levels, resulting in psychosis, coma and potentially death.

Artificial heart maker BiVacor names Axonics CEO as chair of its board

Cohen serves as CEO and as a member of the board at Axonics, which develops sacral neuromodulation technologies. He originally founded Axonics in 2013 and took the Irvine, California-based company public in October 2018. The long-time executive has more than 40 years of experience in the life sciences industry.

In addition to his roles at Axonics, Cohen serves as an independent director of SoniVie. The clinical-stage, venture-backed company develops denervation technology for uncontrolled hypertension.

Cohen now heads up the board at BiVacor, a company making a total artificial heart (BTAH). BiVacor received FDA investigational device exemption (IDE) for the artificial heart last month. It’s now set to conduct a first-in-human clinical feasibility study evaluating the use of the system as a bridge to heart transplant in subjects with biventricular heart failure.

BiVacor expects to initially enroll three patients at the Texas Heart Institute in Houston, beginning in the first half of 2024.

“A total artificial heart is designed to take over the complete function of a patient’s failing heart and represents an advanced treatment option for people waiting on a heart transplant or those who do not qualify for certain reasons,” Cohen said. “The work done by BiVacor over the past 15 years to develop the TAH system is impressive. I’ve spent much of my career in cardiology and consider it a privilege to join Dr. Timms and Dr. Cohn on this amazing journey.”

Aviation and mental health: Is real change on the horizon?